A Phase 2/3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors
Exelixis
Summary
The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Key Inclusion Criteria: * Histologically confirmed, locally advanced/unresectable or metastatic, well-differentiated Grade 1, 2, or 3 NETs of pancreatic origin or extra-pancreatic origin. * Allowed prior lines of therapy, based on the site of NET and functional status. * Documented radiographic disease progression per RECIST 1.1, as assessed by the Investigator based on imaging assessments (computed tomography \[CT\] or magnetic resonance imaging \[MRI\]) within 12 months before randomization. * Measurable disease according to RECIST 1.1 as determined by the Investigator. * Archival tumor tis…
Interventions
- DrugZanzalintinib
Administered as specified in the treatment arm.
- DrugEverolimus
Administered as specified in the treatment arm.
Locations (80)
- Exelixis Clinical Site #43Birmingham, Alabama
- Exelixis Clinical Site #36Phoenix, Arizona
- Exelixis Clinical Site #42Tucson, Arizona
- Exelixis Clinical Site #18Beverly Hills, California
- Exelixis Clinical Site #16Los Angeles, California
- Exelixis Clinical Site #54Palo Alto, California