Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen
University of Nebraska
Summary
The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.
Description
Twelve participants who are patients at the University of Nebraska Medical Center College of Dentistry who are seeking care to extract a posterior tooth (premolar, molar) due to a periodontal or endodontic defect, non-restorable caries or fracture, serial extractions for orthodontic purposes and who are considering a dental implant to replace the extracted tooth, will be enrolled. On the day of extraction, baseline data will be collected: gender, smoking status and medical history. Hemoglobin A1C (HbA1C) will be tested via a simple finger prick to determine if participant's long-term blood glu…
Eligibility
- Age range
- 14–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patient at University of Nebraska Medical Center (UNMC) College of Dentistry * Requires extraction of posterior tooth * Able and willing to provide consent/assent Exclusion Criteria: * Systemic conditions that delay wound healing * Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy
Interventions
- ProcedurePlatelet-rich fibrin (PRF)
Platelet-rich fibrin added to extraction socket
Location
- University of Nebraska Medical Center College of DentistryLincoln, Nebraska