Acute Effects of THC in Older Adult
Yale University
Summary
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
* Ability to provide informed consent * No history (current or past) of unstable or serious medical, neurological or psychiatric conditions. * High school education or greater * No positive pregnancy test and/or lactation/ planning to nurse while in this study * English speaking
Interventions
- DrugDelta-9-THC Low Dose
Active Delta-9-THC administered intravenously over 20 minutes.
- DrugPlacebo
Small amount of sterile ethanol (1-2 mLs), with no THC, administered intravenously over 20 minutes.
- DrugDelta-9-THC Medium Dose
Active Delta-9-THC administered intravenously over 20 minutes
Location
- VA Connecticut Healthcare SystemWest Haven, Connecticut