Washington University School of Medicine
The investigators hypothesize that the combination of eribulin and zanzalintinib will be tolerable and lead to improved progression-free survival (PFS) as compared to eribulin alone based on historical data.
Inclusion Criteria: * Pathologically proven diagnosis of unresectable or metastatic leiomyosarcoma or adipocytic sarcoma. * Progressed on at least 1 line of prior therapy and have received no more than 4 lines of prior therapy. * Measurable disease per RECIST 1.1. * At least 18 years of age. * ECOG performance status ≤ 1 * Adequate bone marrow and organ function within 14 days before first dose of study treatment as defined below: * Absolute neutrophil count ≥ 1.5 K/cumm without granulocyte colony-stimulating factor support within 2 weeks of collection * Platelets ≥ 100 K/cumm without tr…
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1.1 mg/m\^2 dose.
Arctuva estimate
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