A Phase 1, Multicenter, Open-label Study of IBI3020 Treatment in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors
Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD.
Summary
The main purpose of this study is to evaluate the safety and tolerability of IBI3020 and to determine the maximum tolerated dose (MTD) and/or the recommended dose for expansion (RP2D) of IBI3020.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Participants must satisfy all of the following criteria to be enrolled into the study: 1. Participants have the ability to understand and give written informed consent for participation in this trial, including all evaluations and procedures as specified by this protocol; 2. Male or female participants ≥ 18 years old. For Part 1, age ≥ 18 years and ≤ 75 years; 3. Histologically or cytologically confirmed unresectable, locally advanced or metastatic solid tumors which have received available standard therapies and have disease progression, or unacceptable toxic effects, or…
Interventions
- DrugIBI3020
Recombinant anti-CEACAM5 monoclonal antibody - dual-payload conjugate for injection
Locations (9)
- Mayo Clinic - ArizonaPheonix, Arizona
- Mayo Clinic - FloridaJacksonville, Florida
- Mayo Clinic - RochesterRochester, Minnesota
- Montefiore Cancer CenterNew York, New York
- NEXT HoustonHouston, Texas
- NEXT DallasIrving, Texas