Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials (TMS-EEG)
Ramon Diaz-Arrastia
Summary
Patients evaluated at Penn Presbyterian Medical Center for traumatic brain injury (TBI), who sign the informed consent, will undergo assessment of electrophysiologic potentials evoked by transcranial magnetic stimulation (TMS), using the Delphi-MD device (QuantalX Neuroscience Ltd., Saba Israel).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria for Traumatic Brain Injury (Acute, Subacute, Chronic) group: 1. Age 18 years and older 2. Evidence of mechanical energy impacting the head or inertial forces affecting the head 3. Either (A) or (B): 1. Trauma-related abnormality on CT scan on admission 2. If CT normal, documented/verified TBI based on evidence of either loss of consciousness, post-traumatic amnesia, confusion, or post-traumatic symptoms. Exclusion Criteria for Traumatic Brain Injury (Acute, Subacute, Chronic) group: 1. History of disabling pre-existing neurologic disease (Such as epilepsy, brain tu…
Interventions
- DeviceDelphi-MD device (QuantalX Neuroscience Ltd., Saba Israel)
Delphi-MD utilizes the use of transcranial magnetic stimulation evoked electroencephalography (TMS-EEG) for diagnostic purposes in a wide range of neurological disorders. Delphi-MD includes a magnetic stimulator and coil, an EEG amplifier and electrode cap and software for the acquisition and analysis of the data. Delphi-MD stimulation protocol includes low intensities (sub motor thresholds) and frequencies over six stimulation sites (bilateral primary motor cortex, and bilateral dorsolateral prefrontal cortex).
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania