GrayMatters Health Ltd.
The purpose of this research is to learn more about a new treatment for individuals with Major Depressive Disorder (MDD) with heightened symptoms of anhedonia (i.e. loss of pleasure or interest in activities). The treatment is called Prism, and it is a software device intended for a novel form of neurofeedback training to be used in a clinic setting. During this study, the subject will use different techniques to measure brain activities, including magnetic resonance imaging (MRI) and electroencephalography (EEG).
The study is comprised of the Screening Visit, Baseline Assessment, Pre-training Visit, 20 NF Training Visits (two training visits per week over 10 weeks), two Booster NF Training Visits (Week 16, and Week 20, and the 3-Month Follow-up Assessment Visit (Week 24). Participants will receive 20 NF sessions. The study will test the following hypothesis: * H0: M(Anhedonic)RS-EFP = M(Anhedonic)Sham-EFP * H1: M(Anhedonic)RS-EFP ≠ M(Anhedonic)Sham-EFP Where: M(Anhedonic)RS-EFP and M(Anhedonic)Sham-EFP are the mean changes from baseline HDRS-17 score in the Active and Sham arms of the Anhedonic MD…
Inclusion Criteria: 1. Primary Diagnosis of MDD with Anhedonia, established according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM5TR) - HDRS-17 score of ≥20, SHAPS-C score of ≥25. 2. Fluency in written and spoken English. 3. Able intellectually to understand the instructions 4. Ability to give signed, informed consent either written or electronic (via REDCap eConsent). 5. Normal or corrected-to-normal vision and hearing. 6. Ability to adhere to the study schedule. 7. Completed at least one antidepressant treatment course at an adequate dose a…
Participants will complete 20 Prism training sessions. The Prism training sessions take place twice a week over a 10-week period, with a minimum of one night of sleep between sessions. Participants will also receive two single booster sessions, 4 weeks and 8 weeks after their last NF session completed.
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