M.D. Anderson Cancer Center
To learn if reconstruction of the lymphatic system at the time of axillary lymphadenectomy can reduce the risk of developing lymphedema.
Primary Objectives \- To determine the freedom from lymphedema (FFL) rate at 2 years postoperatively in participants with a diagnosis of IBC undergoing ILR at the time of ALND. Secondary Objectives * Estimate the proportion of participants who have lymphedema that persists at 2 years after ILR surgeries. * Determine baseline lymphatic vessel anatomical or functional characteristics associated with increased risk of lymphedema following ILR. * Evaluate changes in systemic inflammatory mediators and systemic immune cell function affiliated with lymphedema development.
Inclusion Criteria: 1. Participants diagnosed with IBC. 2. Participants who have been scheduled for ILR/pLVB by their treating physician/surgeon at the time of their axillary lymphadenectomy for breast cancer 3. Participants willing and able to comply with the study protocol requirements and all study-related visit requirements. 4. Female subjects at least 18 years old and capable of providing consent to participate. 5. Females of childbearing potential must have a negative urine pregnancy test within 36 hours prior to study drug administration and agree to use a medically accepted method of…
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