The Vanguard Study: Testing a New Way to Screen for Cancer
National Cancer Institute (NCI)
Summary
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand how MCDs may work as cancer screening tools. The goal of cancer screening is to reduce the burden of cancer by identifying cancers before they show symptoms or signs, when treatment is likely to be most effective. In this study, adults aged 45-75 without cancer will be randomly assigned to one of 3 groups: 2 separate MCD test groups or a control group. These two MCD tests will not be compared to each other but will be compared to cancers detected in the control group. This study will provide early information on how well MCD tests perform as cancer screening tools. It will also help researchers understand how patients and their doctors make decisions about their care when the MCD test result comes back as normal (negative) or abnormal (positive).
Description
PRIMARY OBJECTIVES: I. Assess the feasibility of recruitment and adherence to protocol-required baseline and follow-up data and blood collection. II. Assess the feasibility of achieving representative enrollment across participating recruitment sites. SECONDARY OBJECTIVES: I. To assess the impact of participant blinding on willingness to participate, adherence to protocol required baseline and follow-up data, blood collection, and rates of standard of care screening. II. To determine the timeliness of returning test results to participants. III. To understand the factors contributing to l…
Eligibility
- Age range
- 45–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Ages 45-75 years old * Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment * Agree to allow collection of information from their medical records for study-related purposes * Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic * Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion Exclusion Criteria: * Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years * Note: Persons with a hi…
Interventions
- ProcedureBiospecimen Collection
Undergo blood collection
- DeviceDevice Usage
Evaluation of MCD tests
- OtherElectronic Health Record Review
Obtain health data
- ProcedureMulti-Cancer Detection Test
Undergo Shield MCD test
- ProcedureMulti-Cancer Detection Test
Undergo Avantect MCD test
- OtherQuestionnaire Administration
Study specific questionnaires
Locations (37)
- Kaiser Permanente-Division of ResearchPleasanton, California
- Keefe Memorial HospitalCheyenne Wells, Colorado
- Kaiser Permanente-FranklinDenver, Colorado
- Poudre Valley HospitalFort Collins, Colorado
- Cancer Care and Hematology-Fort CollinsFort Collins, Colorado
- UCHealth Greeley HospitalGreeley, Colorado