Amino Acids for the Infant at Risk for Acute Kidney Injury After Cardiac Surgery: A Pilot Study
Stanford University
Summary
The purpose of this study is to assess the feasibility of amino acid infusions in pediatric cardiac surgery patients.
Eligibility
- Age range
- 0–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Undergoing cardiac surgery and expected to be high risk Exclusion Criteria: * preoperative extracorporeal organ support * CKD history (GFR\<60ml/min/1.73m2 \[≤1year\] and GFR\<90ml/min/1.73m2 \[\>1 year\]) * serum creatinine defined preoperative AKI.
Interventions
- DrugAmino Acids
The participants receive a continuous infusion of a balanced mixture of amino acids (Trophamine) in a dose of 2g/kg/day (max 100g/day) starting at the time of cardiac surgery up to 3 days
- DrugPlacebo
The participants receive a continuous infusion of a lactated ringers (placebo), equivalent volume to amino acids, starting at the time of cardiac surgery up to 3 days
Location
- Lucile Packard Children's HospitalPalo Alto, California