Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease Using [18F]PI-2620: A High-resolution PET Imaging Study Using NeuroEXPLORER (NX PI-2160 in PD)
Michael J. Fox Foundation for Parkinson's Research
Summary
The study aims to evaluate the burden of tau pathology in people with Sporadic and LRRK2 PD via in vivo imaging using the tau tracer, \[18F\]PI-2620, and a high resolution PET camera, NeuroEXPLORER.
Description
The purpose of this study to compare how well \[18F\] PI-2620, a PET radiotracer targeting Tau protein, bind to brain regions in people with Parkinson's disease (PD), Progressive Supranuclear Palsy, Corticobasal Syndrome, and healthy volunteers. The study is planned to be conducted over a period of two years. The study aims to assess the tau burden in PD compared to diseased and healthy controls with PET imaging using \[18F\]PI-2620 and utilizing the new NX PET camera. The study will include subjects already enrolled in the PPMI study to enable efficient enrollment. The study will utilize cli…
Eligibility
- Age range
- 45–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: General inclusion criteria include the following: 1. Ability to comply with the study procedures and attend follow-up visits. 2. Written informed consent from the participant or legal guardian. 3. Male or Female between 45 years and 85 years of age (Females must meet additional criteria specified below, as applicable) a. Females must be of non-childbearing potential or using a highly effective method of birth control 14 days prior to until at least 24 hours after injection of \[18F\]PI-2620 or DaTscan. i. Non-childbearing potential is defined as a female that must be eit…
Interventions
- Drug[18F]PI-2620
All participants will undergo PET imaging using the \[18F\]PI-2620 tau-binding tracer.
Location
- Institute for Neurodegenerative Disorders / XingImaging, LLCNew Haven, Connecticut