Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
University of Colorado, Denver
Summary
This study plans to learn more about using contrast enhanced ultrasound (CEUS) in brain tumor surgery. The goal of glioma brain tumor surgery is to remove as much of the glioma as possible. Tumor tissue that is close to normal brain tissue can look very similar. This can make it difficult for the surgeon to remove all the tumor. In this study, we hope to learn if using CEUS during brain tumor surgery will allow the brain surgeon to better see and remove all the tumor tissue.
Eligibility
- Age range
- 18–95 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Able to sign and date the consent form * Stated willingness to comply with all study procedures and be available for the duration of the study * Be a male or female aged 18-95 * Have a planned standard of care surgery for presumed primary or known recurrent glioma * WHO performance status \</= 2 (equivalent Karnofsky Performance Status, KPS\>/= 70) * Patient of childbearing potential must have a negative pregnancy test within 14 days of inclusion Exclusion Criteria: * Patient at high risk of surgical site infection (e.g., 2 or more previous craniotomies/neurosurgery wi…
Interventions
- Combination ProductDefinity contrast during ultrasound
Definity contrast injection given just prior to brain tumor surgery. Contrast enhanced ultrasound during brain tumor surgical resection to aid in brain tumor visualization.
Location
- University of Colorado Anschutz Medical CampusAurora, Colorado