Washington University School of Medicine
This open-label, randomized phase II trial evaluates the dose delivery, tolerance, and efficacy of two dosing regimens of lenvatinib among patients with radioactive iodine resistant (RAIR) differentiated thyroid cancer (DTC).
Inclusion Criteria: * Histologically confirmed DTC, defined as papillary, follicular, or Hurthle Cell thyroid cancer. Papillary has several sub-types such as tall-cell and columnar cell, which are all allowed. * Patient must have incurable RAIR DTC, defined as disease not amenable to cure by surgery AND meeting one or more of the following criteria: * one or more sites of disease that do not take up RAI. * disease progression on RAI (given within the last 12 months). * receipt of cumulative dose of RAI of ≥ 600mCi. * patient declines or is ineligible for surgery and/or RAI. * Measura…
Lenvatinib is an oral drug which will be administered on an outpatient basis at a dose of 24 mg daily or 10 mg daily for an unlimited number of cycles.
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