BAF_FRontier-1, A First-in-Human, Phase 1 Trial to Assess Safety, Tolerability, and Preliminary Efficacy of LY4152199, a B-cell Activation Factor Receptor (BAFF-R) T-Cell Engager Bispecific Antibody in Adult Participants With Previously Treated B-cell Malignancies
Eli Lilly and Company
Summary
The purpose of this study is to find the best dose of the drug and measure the safety and efficacy of LY4152199 in participants with previously treated B-cell lymphoma.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Estimated life expectancy of greater than or equal to (≥)12 weeks as judged by the Investigator. * Participants with select tumor types must have measurable or assessable disease as defined below: * Must have at least 1 bi-dimensionally measurable lesion or in the absence of measurable lymphadenopathy, documentation of bone marrow involvement. * Must be able to comply with inpatient/outpatient treatment, laboratory monitoring, and required clinic visits for the duration of trial partic…
Interventions
- DrugLY4152199 - IV
Administered by IV infusion
Locations (50)
- City of HopeDuarte, California
- University of Colorado Denver - School of Medicine - Anschutz Medical CampusAurora, Colorado
- Colorado Blood Cancer InstituteDenver, Colorado
- Yale University School of Medicine - Yale Cancer CenterNew Haven, Connecticut
- The University of Chicago Medical Center (UCMC)Chicago, Illinois
- University of IowaIowa City, Iowa