PARP-1 Targeting With the Novel Radiotracer [18F]FTT in Pancreatic Neuroendocrine Tumors
Abramson Cancer Center at Penn Medicine
Summary
A pilot study to evaluate the expression of PARP-1 in patients with pancreatic neuroendocrine tumors will be conducted. This will be done via the use of a novel PET imaging agent, \[18F\]FluorThanatrace (\[18F\]FTT). A total of 12 patients will be enrolled. Patients will undergo a study imaging assessment using a whole-body PET CT scanner. Dynamic images will be obtained beginning immediately prior to the administration of 10 mCi of \[18F\]FTT (±20%) for a total of 60 minutes. A static scan may subsequently be obtained up to 90 minutes post radiotracer injection, per the PI's discretion. \[18F\]FTT uptake will be measured on the PET scan and correlated with two molecular outcomes.
Description
Pancreatic neuroendocrine tumors are a rare disease entity for which there are relatively limited treatment options. Due to the nature of this malignancy, preclinical models have also been challenging to develop. It is known that the majority of these tumors harbor a mutation in MEN1, DAXX or ATRX, all of which are thought to be associated with abnormal DNA repair mechanisms, including homologous recombination. Defects in homologous recombination often render a tumor susceptible to treatment with a PARP inhibitor but the activity of PARP inhibition in pancreatic neuroendocrine tumors has not b…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Patients must be ≥ 18 years of age. 2. Clinical diagnosis of a metastatic or unresectable grade 1, grade 2 or grade 3 (G1/G2/G3) pancreatic neuroendocrine tumor. 3. Have at least one lesion on clinical imaging (e.g. CT/MRI/PET/CT/ultrasound) that is ≥ 1.5 cm in size. 4. Patients may be receiving any form of treatment or not be undergoing current treatment. 5. Willing to consent to use of tumor tissue (fresh frozen and/or clinical pathology specimens) collected as part of another study or biobank collection or clinical procedure. 6. Must be informed of the investigationa…
Interventions
- Drug[18F]FluorThanatrace
Intravenous injection of ≤ 12 mCi of \[18F\]FTT for whole-body PET CT dynamic imaging and subsequent static scan.
Location
- University of Pennsylvania, Perelman Center for Advanced MedicinePhiladelphia, Pennsylvania