Memorial Sloan Kettering Cancer Center
This study will test whether MB-CART19.1 is a safe and effective treatment for central nervous system lymphoma (CNSL). This study will test different doses of MB-CART19.1 to find the highest dose that causes few or mild side effects in participants.
Inclusion Criteria: * Men and women who are at least 18 years of age on the day of consenting to the study. * Histologically documented primary or secondary central nervous system lymphoma of DLBCL subtype * Relapsed/refractory primary or secondary CNSL patients. All relapsed//refractory patients need to have received at least one prior CNS-directed methotrexate-based therapy. There is no restriction on the number of recurrences. * For relapsed patients, parenchymal lesions must have unequivocal evidence of disease progression on imaging (MRI of the brain or head CT) within 21 days of study c…
MB-CART19.1 will be infused as a single infusion during an inpatient admission.