Dynorphin/Kappa Opioid Receptor Signaling Role in Ketamine's Anti-suicidal Ideation Effect
New York State Psychiatric Institute
Summary
This study explores how stress, suicidal thoughts, and ketamine's effects are connected in people with major depressive disorder. Stress increases the risk for suicidal thoughts, but the biological basis is unclear. Ketamine may help reduce suicidal thoughts by affecting stress-linked brain systems. This study will use smartphone tracking to monitor real-time responses to stress and positron emission tomography (PET) brain scans to study how ketamine affects brain pathways related to stress and suicidal thoughts in depressed individuals.
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * DSM5 unipolar major depressive episode * Persons of child-bearing potential must agree to use an acceptable method of birth control throughout the study. Exclusion Criteria: * Current or past ketamine abuse or dependence ever (lifetime) * Any medical contraindication to ketamine, including prior ineffective trial of or medically significant adverse reaction to ketamine. * Clinically significant EKG abnormality in terms of ketamine administration (e.g., Ventricular tachycardia, evidence of myocardial ischemia, symptomatic bradycardia, unstable tachycardia, second degree…
Interventions
- DrugKetamine hydrochloride infusion
single racemic ketamine hydrochloride 0.5 mg/kg infusion
Location
- New York State Psychiatric InstituteNew York, New York