A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event
Eli Lilly and Company
Summary
The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Have Lp(a) ≥175 nanomoles per liter (nmol/L) * Meet one of the following criteria: * Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening * Are at risk for a first ASCVD event, defined as one or more of the following: * Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event * A high coronary artery calcium (CAC) score * Reduc…
Interventions
- DrugMuvalaplin
Administered orally
- DrugPlacebo
Administered orally
Locations (751)
- Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLCGilbert, Arizona
- Axsendo Clinical Research - Peak Heart & Vascular - PhoenixPhoenix, Arizona
- Clinical Research Institute of Arizona (CRI) - Sun City WestSun City West, Arizona
- Southwest Kidney Institute - SurpriseSurprise, Arizona
- Pima HeartTucson, Arizona
- National Heart InstituteBeverly Hills, California