A Multicenter, Open-label, Phase 1b/2 Trial of ABL103, a Bispecific Antibody of B7-H4 and 4-1BB, in Combination With Pembrolizumab With/Without Taxane in Subjects With Selected, Progressive, Locally Advanced (Unresectable) or Metastatic Solid Tumors
ABL Bio, Inc.
Summary
This study is to assess the safety and antitumor activity of ABL103 plus pembrolizumab, with or without taxane, in advanced or metastatic solid tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subject must understand and be willing to provide informed consent and be able to comply with the study procedures and restrictions. * Subjects must be ≥18 years of age on the day of signing the informed consent form (ICF). * Subject must have a histologically or cytologically confirmed locally advanced unresectable, or metastatic solid tumor. * Subject must be relapsed or be refractory to available standard therapy or they must be intolerant of available standard therapy. * Subject must meet Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 assessed 7…
Interventions
- DrugABL103
IV infusion
- DrugKEYTRUDA® (pembrolizumab)
IV infusion
- DrugTaxane
IV infusion
Locations (6)
- UH Cleveland Medical CenterCleveland, Ohio
- PASO MedicalFrankston, Victoria
- Seoul National University Bundang HospitalSeongnam
- Seoul National University HospitalSeoul
- Asan Medical CenterSeoul
- Samsung Medical CenterSeoul