Pilot Trial of Non-invasive Electrostimulation in Chronic Ocular Graft-vs-Host Disease
Zhonghui K. Luo, MD, PhD
Summary
This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.
Description
The trial is to test whether transcutaneous electrical stimulation (TES) may be an effective new type of non-invasive treatment for patients who are diagnosed with chronic ocular Graft-vs-Host Disease. Such a treatment can potentially decrease the need for the patients to apply eye drops frequently, repair the damage caused by chronic ocular Graft-vs-Host Disease, and improve the comfort of the eyes naturally.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of chronic ocular graft vs. host disease (oGVHD) (ICCGVHD criteria probable or definite) * OSDI score of 22 or higher * NEI corneal staining score (or modified NEI score) of 2 or higher. Exclusion Criteria: * Patients with any open wound on the eyelid. * Patient with any active cornea ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma or other active pathology per PI's discretion. * Patient with a pacemaker or ICD. * Patient currently pregnant or with a potential to be pregnant during the study. * Patie…
Interventions
- DeviceElectrodes with Currents
Electrodes will be placed on the cheeks and forehead, and treated with an amplitude of 300 µA for 30 mins
- DeviceElectrodes without Currents
Electrodes will be placed on the cheeks and forehead, and treated with an no amplitude for 30 mins
Location
- Massachusetts Eye and Ear - Longwood CampusBoston, Massachusetts