Rocklatan Trial With Optical Coherence Tomography Study of Retinal Perfusion
Oregon Health and Science University
Summary
The main purpose of this study is to learn more about how Rocklatan eye drops affects blood flow in the eye. The secondary purpose is to see if our study devices can detect changes in blood flow before and after instillation of Rocklatan.
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Patients with both eyes with open angle glaucoma. 2. Abnormal VF (glaucomatous pattern with PSD abnormal at p\<0.05 or GHT outside normal limits) on most recent two clinic visits on chart review 3. Glaucomatous disc abnormality on chart review and confirmed on baseline disc photograph 4. Overall average NFL thickness \> 55 μm measured by Heidelberg Spectralis OCT -Glaucoma Module Premium Edition (chart review), consistent with early glaucoma 5. NFLP-CD deficit (below 5 percentile of normal) in any of the 8 sectors on the initial baseline visit 6. The difference in basel…
Interventions
- DrugRocklatan eye drops will be instilled nightly in one eye diagnosed with glaucoma for up to 12 months.
The eye not selected as the study eye will be used for comparison so both eyes will be imaged with the study devices to assess blood flow changes.
- DeviceTwo optical coherence tomography (OCT) devices will be used to assess blood flow changes.
One OCT device is FDA-cleared while the other is still experimental. Both devices assess blood flow in different ways.
Location
- Casey Eye Institute - Oregon Health & Science UniversityPortland, Oregon