The Miriam Hospital
The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels. The main questions it aims to answer are: Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood? Participants will: Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers
Lipoprotein(a), or Lp(a), is a genetically determined cholesterol particle that increases the risk of heart disease and stroke. High levels of Lp(a) affect about 1 in 4 people, and there are no approved treatments that directly reduce its harmful effects. One reason Lp(a) is thought to be harmful is that it carries oxidized phospholipids, which promote inflammation and blood clotting. 2-hydroxybenzylamine (2-HOBA, also known as Hobamine) is a naturally occurring compound that neutralizes reactive molecules responsible for forming oxidized lipids. Preclinical studies and early human trials sug…
Inclusion Criteria: * Males and females aged 18-69 years. * Elevated Lp(a) levels ≥ 90 mg/dL. * Able to provide informed consent and adhere to study schedules. * Willing to follow a physician-recommended diet during the study. Exclusion Criteria: * Pregnant, planning pregnancy during the study period, or currently breastfeeding. * Individuals with established cardiovascular disease * Planning major changes in diet or exercise routines. * Experienced \>20% weight change in the past 3 months. * Diagnosed with malabsorption syndrome or chronic diarrhea. * Abnormal liver, kidney, or thyroid fun…
Participants will take oral 2-hydroxybenzylamine (2-HOBA, Hobamine), a dietary supplement with Generally Recognized as Safe (GRAS) status. The study dose is 400 mg three times daily with meals for 6 weeks.
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