A Randomized, Double-Blind, Placebo-Controlled Trial Comparing 48-Hour Post-Operative Administration of Oral Versus Intravenous Acetaminophen in Patients Undergoing Lumbar Spine Fusion Surgery
Stanford University
Summary
The goal of this study is to compare whether oral or intravenous acetaminophen works better for pain control in patients undergoing lumbar spine fusion surgery
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Plan for open lumbar laminectomy and fusion surgery (1-3 levels) * Able to provide written informed consent * Must be able to swallow pills Exclusion Criteria: * Medical contraindications to acetaminophen * Emergency surgery * Chronic pain unrelated to surgery * Pregnancy
Interventions
- DrugAcetaminophen Oral Tablet
Participants take 1000mg by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
- Drugplacebo oral tablet
Participants take one placebo tablet (matchable to tylenol) by mouth every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
- DrugAcetaminophen infusion
Participants take 1000mg by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
- DrugPlacebo infusion
Participants take 1000mg placebo by intravenous infusion over 15 minutes every 6 hours for a total of 8 doses (48 hours total) starting within 2 hours after their spine surgery.
Location
- Stanford UniversityStanford, California