Detection of Phosphorylated Alpha-synuclein Through Routine Colonoscopy to Diagnose Parkinson's Disease and Related Disorders
CND Life Sciences
Summary
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.
Description
Brief Summary What is this study about? This study is testing whether doctors can detect signs of Parkinson's disease by taking small tissue samples from the colon during a routine colonoscopy. Researchers want to see if they can find a specific protein called alpha-synuclein that builds up in people with Parkinson's disease. Why is this study important? Currently, Parkinson's disease is diagnosed mainly by observing symptoms like tremors and movement problems. However, by the time these symptoms appear, the disease has already progressed significantly. Finding a way to detect the disease ea…
Eligibility
- Age range
- 40–99 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults 40 to 99 years of age * Patients with a confirmed clinical diagnosis of Parkinson's disease by UKPDS Brain Bank Criteria * Patients who have agreed to undergo a routine colonoscopy as part of their surveillance for colon cancer or exclusion of other gastrointestinal diseases Exclusion Criteria: * Use of anticoagulants (Plavix 75 mg or aspirin up to 325 mg alone is allowed) * History of colon cancer * Recent gastrointestinal illness or surgical procedures * Pregnant or planning to become pregnant before the scheduled colonoscopy * Significant cognitive impairment…
Interventions
- Diagnostic TestNo Intervention: Observational Cohort
No Intervention: Observational Cohort
Location
- Oregon Health & Science UniversityPortland, Oregon