A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneration
Apellis Pharmaceuticals, Inc.
Summary
A Phase 2, Randomized, Placebo-controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL-3007 in Combination with Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed with Geographic Atrophy Secondary to Age-Related Macular Degeneration
Eligibility
- Age range
- 60+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * The study eye must meet all inclusion criteria. If both eyes meet the inclusion criteria, the eye with better normal luminance visual acuity at the screening visit will be designated as the study eye. If both eyes have the same visual acuity, the right eye will be used as the study eye. * Aged ≥60 years * Clinical diagnosis of GA of the macula secondary to AMD in one or both eyes, as determined by the investigator and confirmed by the reading center * NL-BCVA of 50 letters or better using early treatment diabetic retinopathy study (ETDRS) charts (approximately 20/100 Sne…
Interventions
- DrugAPL-3007, pegcetacoplan (APL-2)
Complement C3 inhibitor
- DrugAPL-3007, pegcetacoplan (APL-2)
Complement C3 Inhibitor
- OtherPlacebo, Syfovre
Complement C3 Inhibitor
Locations (43)
- Barnet Dulaney Perkins Eye Center (01018)Mesa, Arizona
- Associated Retina Consultants - PhoenixPhoenix, Arizona
- Retinal Research Institute, LLC (01021)Phoenix, Arizona
- California Retina Consultants (CRC) - Bakersfield OfficeBakersfield, California
- The Retina Partners - EncinoEncino, California
- Retina Consultants of Orange County - Fullerton OfficeFullerton, California