A Phase 1, Randomized, Placebo-controlled Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Emraclidine Following Multiple Ascending Oral Doses in Healthy Elderly Subjects
AbbVie
Summary
This study is to assess how oral emraclidine moves through the body of healthy elderly adult participants, and assess adverse events, and tolerability.
Eligibility
- Age range
- 65–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * BMI is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters. * Body weight \> 45 kg at the time of screening and upon initial confinement. * A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG. Exclusion Criteria: * History of any clinically significant cardiac, respiratory (except mild asthma as a child), renal, hepatic, gastrointestinal, genitourinary, immunologic…
Interventions
- DrugEmraclidine
Oral tablets
- DrugPlacebo
Oral tablets
Locations (4)
- Altasciences Clinical Los Angeles /ID# 276854Cypress, California
- K2 Medical Research, LLC /ID# 276636Maitland, Florida
- Clinical Pharmacology Of Miami /ID# 276856Miami, Florida
- Acpru /Id# 276996Grayslake, Illinois