The Moody Longevity Trial: Tirzepatide to Slow Biological Aging
The University of Texas Medical Branch, Galveston
Summary
This pilot clinical study aims to investigate the potential effects of tirzepatide on biological aging in older adults. In this novel study, 90 adults aged 55-70 years with an indication for tirzepatide weight-loss therapy will be randomized to receive either tirzepatide 2.5 mg subcutaneously (SC) weekly or no drug for 24 weeks, followed by 12 weeks off the drug. Since tirzepatide is already recognized as a highly effective weight-loss agent in this population, the primary focus will not be on measuring weight loss. Instead, the study will document the effects of tirzepatide on markers of aging, physical function, and overall health.
Description
Primary Objective To estimate the potential effect of tirzepatide on biological aging using epigenetic age (based on established DNA methylation-based clocks), among people 55-70 years of age with an indication for tirzepatide weight loss therapy. The principal investigator (PI) will measure DNA methylation-based aging clocks (DNAmAge, DNAm PhenoAge, DNAm GrimAge and DunedinPACE) before and after a 24-W course of tirzepatide. The primary analysis will determine whether tirzepatide treatment leads to a statistically significant change in biological age as indicated by these clocks. The PI will…
Eligibility
- Age range
- 55–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 55-70 years 2. BMI ≥ 30 kg/m² or ≥ 27 kg/m² if also with ≥ 1 weight-related comorbidity 3. If taking anti-inflammatory or blood-pressure-/lipid-/glucose-lowering medications, no change in dose for ≥12 weeks prior to entry and no plans to dose escalate for the study duration 4. Willing and able to provide written informed consent and undergo all required study procedures Exclusion Criteria: 1. BMI \>35 kg/m² 2. Uncontrolled or end-stage, comorbid, cardiometabolic disease, in the opinion of the site investigator 3. Significant neurocognitive impairment, in the opini…
Interventions
- DrugZepbound
Auto injectors with a 2.5 mg dosage are given subcutaneously weekly.
Location
- University of Texas Medical BranchGalveston, Texas