A Phase 1a/1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BG-75202, Alone and in Combination With Other Agents in Patients With Advanced Solid Tumors
BeOne Medicines
Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75202 (KAT6A/B inhibitor) alone and in combination with other therapies in participants with breast cancer and other advanced solid tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Part 1A: Participants with histologically or cytologically confirmed advanced, metastatic breast cancer and other solid tumors who have exhausted, are intolerant of all available standard of care therapies, and/or without available standard of care therapies. * Part 1B and Part 2A: Participants with advanced breast cancer with 1 to 3 prior lines of systemic therapy in the metastatic setting. Prior lines in the advanced/ metastatic setting may not exceed 2 lines of chemotherapy (inclusive of antibody-drug conjugate with cytotoxic payload). * Parts 2B and 2C: Participants…
Interventions
- DrugBG-75202
Administered orally.
- DrugCDK4 Inhibitor
Administered orally.
- DrugEstrogen Receptor Antagonist
Administered by intramuscular injection.
- DrugAromatase Inhibitor
Administered orally.
Locations (23)
- University of Alabama At Birmingham HospitalBirmingham, Alabama
- Yale Cancer CenterNew Haven, Connecticut
- Washington University in St LouisSt Louis, Missouri
- Next Oncology AustinAustin, Texas
- The University of Texas Md Anderson Cancer CenterHouston, Texas
- Blacktown Cancer and Haematology CentreBlacktown, New South Wales