RETURN: Recovery of Physical Function After Critical Illness In Older Adults
University of Kentucky
Summary
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.
Description
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness: Aim 1: Determine the long-term trajectory of muscle strength, physical function and AD…
Eligibility
- Age range
- 18–99 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * adult patients (≥40 years of age) * patients who have survived an ICU admission of at least 72 hours * diagnosis of acute lung injury or sepsis are eligible. Exclusion Criteria: * individuals who were not ambulatory prior to ICU admission, * not expected to survive at least 6 months, * have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing, * have a pre-existing geriatric syndrome that were confound recovery trajectory
Location
- University of Kentucky, Lexington, Kentucky 40536Lexington, Kentucky