The Association Between Gut Microbiota Diversity and Postpartum Depression： A Prospective Pilot Study
Massachusetts General Hospital
Summary
This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression. Biological samples will be collected before and after delivery to determine whether specific patterns in gut bacterial composition are linked to emotional states. The purpose of the research is to improve understanding of whether such microbial changes can help identify individuals at higher risk for postpartum depression, enabling earlier recognition and intervention.
Description
This prospective observational pilot study is designed to explore the relationship between gut microbial diversity and depressive symptoms during the early postpartum period. Postpartum depression is one of the most frequent complications after childbirth and has a substantial impact on the physical and psychological well-being of mothers and infants. The study investigates whether differences in gut microbial composition are associated with the development of depressive symptoms following childbirth. Pregnant individuals aged eighteen years or older planning cesarean delivery at Massachusett…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Age 18 years or older * Gestational age at least 36 weeks, planned cesarean delivery * Ability to understand study procedures and provide informed consent * Voluntary agreement to participate in the study Exclusion Criteria: * Gastrointestinal disorders or recent antibiotic use that significantly alters gut microbiome * Diagnosis of severe mental illness such as schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder with psychotic features * Medication use during pregnancy known to influence gut microbiota, including antidepressants, an…
Location
- Meikun WangBoston, Massachusetts