Massachusetts General Hospital
This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology among adults with subjective cognitive decline, mild cognitive impairment, or Alzheimer's disease and objective indicators of seeding AD pathology
Inclusion Criteria: 1. Age 55 and older, male and female; 2. Subjective Cognitive Impairment or MCI or AD dementia per NIA-AA 2011 criteria; 3. Clinical Dementia Rating \< or = to 2 and Mini Mental Status Exam \> or = to 16; 4. Modified Hachinski Ischemic Score \< or = to 4 5. Geriatric Depression Scale - 15 \< 6 documenting absence from significant depressive syndromes 6. Other medications including non-disease modifying for MCI and AD (e.g., acetylcholine esterase inhibitor, N-methyl D-aspartate receptor antagonist) stable \> or = to 3-months ; 7. Biomarker evidence of AD pathology: Plasma…
parthenolide plus ipriflavone
Arctuva estimate
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