Evaluation of SPM™ Topical Cosmetic Application on Skin Appearance, Hydration, and Barrier Support in Healthy Adults
Biocoz Global Pte. Ltd.
Summary
This is an exploratory, cosmetic-use study evaluating the effects of Super Protein Multifunction (SPM™), a topical peptide-based formulation, on skin appearance, hydration, and barrier-related characteristics in healthy adults. The study aims to collect preliminary biophysical and histologic data on cosmetic skin changes following six weeks of SPM™ use. Participants will apply the product to a designated skin area while a matched contralateral area serves as the untreated comparison site. Skin hydration, transepidermal water loss (TEWL), and tissue markers of skin structure and barrier integrity will be assessed before and after product use. The study includes noninvasive measurements and small punch biopsies at two timepoints.
Description
SPM™ is a multi-component peptide formulation designed to support skin health and barrier function. Preclinical data demonstrate reduced expression of inflammatory cytokines and potential improvements in epidermal physiology. Prior clinical data in eczematous skin suggest reductions in inflammation and improvements in clinician-assessed skin ratings. This pilot study extends investigation into healthy adults to characterize cosmetic and structural skin attributes associated with SPM™ use. Participants aged 20-75 years will undergo screening, informed consent, and baseline assessments. Study p…
Eligibility
- Age range
- 20–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Generally healthy with no systemic or active dermatologic diseases. 2. Willing and able to apply topical product daily for 6 weeks. 3. Able to provide written informed consent. 4. Willing to undergo skin biopsies and follow study procedures. Exclusion Criteria: 1. History of skin cancer or other malignancy within the past 10 years. 2. Active or chronic dermatologic conditions (e.g., eczema, psoriasis, acne, rosacea). 3. Known allergy or sensitivity to components of the investigational product. 4. Current use of systemic corticosteroids or immunosuppressants. 5. Pregna…
Interventions
- ProcedureSkin biopsy
Skin biopsies (3-6 mm) will be performed at two time points: Baseline (prior to initiation of SPM™ application) End of product-use period (after 6 weeks of twice-daily application) These samples will be analyzed for cosmetic-related skin structure and protein expression characteristics (e.g., filaggrin levels and barrier markers).
- OtherCorneometer® Measurement
Noninvasive skin hydration assessment using the Corneometer® instrument at baseline and after 6 weeks. The device quantifies the moisture content of the stratum corneum through dielectric constant measurement.
- OtherTewameter® Measurement
Noninvasive transepidermal water loss (TEWL) measurement using the Tewameter® device to assess barrier function before and after the 6-week product-use period.
Location
- Project Quality of LifeWest Hollywood, California