Digital Health Technologies For Monitoring Disease Symptoms in Progressive Supranuclear Palsy and Dementia With Lewy Bodies
BioSensics
Summary
Progressive supranuclear palsy (PSP), mild cognitive impairment with Lewy bodies (MCI-LB), and Dementia with Lewy Bodies (DLB) are severe neurodegenerative diseases that cause significant motor impairment impacting daily function. Researchers at BioSensics, Johns Hopkins School of Medicine, Massachusetts General Hospital and their collaborators aim to conduct an analytical and clinical validation of wearable-based digital health technologies for monitoring upper and lower limb function in PSP, MCI-LB and DLB that could enable frequent, at-home monitoring and be incorporated into future clinical trials.
Description
PSP is a severe and rapidly progressive frontotemporal lobar degeneration (FTLD) syndrome that lacks effective treatment and leads to a rapid onset of dementia, disability, and eventually death. Dementia with Lewy bodies (DLB) is the second most common type of neurodegenerative dementia after Alzheimer's disease that severely impacts daily function and shortens lifespan. Mild cognitive impairment with Lewy bodies (MCI-LB) is an earlier stage where cognitive impairment is noticeable, but does not significantly interfere with living to the degree as seen in DLB. Both PSP and DLB cause significan…
Eligibility
- Age range
- 40–89 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Male and female participants aged 40-89 meeting clinical diagnostic criteria for probable PSP, probable MCI-LB or probable DLB. * Able to be present for all study procedures, complete questionnaires and assist during home data collection. * Eligible participants must be fluent in reading and speaking English and must be capable of providing informed consent based on the principal investigator's judgment. * Must have a caregiver or study partner who is willing and able to assist with all study-related procedures. * Ambulatory (able to take 10 steps with minimal support su…
Locations (2)
- Johns Hopkins University School of MedicineLutherville, Maryland
- Massachusetts General HospitalBoston, Massachusetts