Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring
Texas A&M University
Summary
Noninvasively monitoring insulin is crucial for advancing precision nutrition and promoting healthy living by enabling a deeper understanding of individual metabolic responses to dietary intake. Insulin is a key regulator of blood sugar and energy metabolism, and its dysregulation is linked to conditions such as diabetes, obesity, and metabolic syndrome. By noninvasively tracking insulin levels, individuals can gain real-time insights into how their body processes different foods, allowing for the personalization of diets to optimize metabolic health, manage weight, and reduce disease risk. This approach also empowers proactive lifestyle adjustments to maintain insulin sensitivity, improve glycemic control, and enhance overall well-being. Decentralized insulin quantification in biofluids, including saliva and serum, based on lateral flow assay or electrochemical sensor has been reported. However, these approaches have poor sensitivity and fail to quantify insulin with a high temporal resolution.
Description
The goal of the proposed research is to develop a wearable device that can directly stimulate sweat secretion and rapidly quantify the concentration of insulin in sweat. In stark contrast to a blood draw and subsequent insulin quantification in a clinical lab, the envisioned wearable sweat sensor can noninvasively and rapidly quantify insulin at any desired time at home. This study will validate the performance of the wearable devices for in situ quantification of insulin in sweat and determine the concentration correlation between sweat, dermal interstitial fluid, and blood. The study will t…
Eligibility
- Age range
- 18–90 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion criteria: * Age * 18-30 years old * 50-90 years old * BMI between 22 and 35 kg/m2 * Ability to walk, sit down, and stand up (independently or with a walking assistance device) * Willingness to lay supine in bed for up to 9 hours * Willingness and ability to comply with the protocol Exclusion criteria * Known allergy to any of the components of the meal or agents used for the application of the devices * Sunflower oil * Maltodextrin * Whey protein * Pilocarpine solutions * Established diagnosis and active treatment of chronic disease: insulin-dependent diabetes, activ…
Interventions
- OtherStandardized meal
We will use Whey powder (60g) as protein, Maltodextrin (Polycose; 170g) as carbohydrate, and Sunflower Oil (48g) as the fat source. The meal is mixed and flavored using vanilla sugar-free instant pudding.
Location
- Texas A&M UniversityCollege Station, Texas