A Phase 3 Randomized Study Comparing JNJ-79635322 and an Anti-BCMAxCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti CD38 Antibody
Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion: * Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: 1. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria 2. Measurable disease at screening as assessed by central laboratory * Received at least 3 prior lines of antimyeloma therapy including a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-cluster of differentiation (CD)38 antibody * Documented evidence of progressive disease (PD) or failure to achieve a response (that is partial response \[PR\] or better) to the last line of thera…
Interventions
- DrugJNJ-79635322
JNJ-79635322 will be administered as SC injection.
- DrugTeclistamab
Teclistamab will be administered as SC injection.
Locations (43)
- USC Norris Comprehensive Cancer CenterLos Angeles, California
- University of Connecticut Health CenterFarmington, Connecticut
- Yale Cancer CenterNew Haven, Connecticut
- Florida Cancer Specialists & Research InstituteFort Myers, Florida
- Moffit Cancer centerTampa, Florida
- Emory UniversityAtlanta, Georgia