A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3561774 (Solbinsiran) in Adults With Severe Hypertriglyceridemia
Eli Lilly and Company
Summary
The purpose of this study is to evaluate the safety and efficacy of solbinsiran in lowering triglycerides and other lipid measures compared to placebo in participants with severe hypertriglyceridemia. Participants will receive two subcutaneous injections.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL), based on medical history * Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (at least 7 days apart) * Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per square meter (kg/m2) (inclusive) Exclusion Criteria: * Have had a major atherosclerotic cardiovascular event within the past 3 months prior to screening * Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome * Have a history of or planned treatment involving…
Interventions
- DrugSolbinsiran
Administered SC
- DrugPlacebo
Administered SC
Locations (40)
- Axsendo Clinical Research - Peak Heart & Vascular - PhoenixPhoenix, Arizona
- Synexus Clinical Research US, Inc./Orange Grove Family PracticeTucson, Arizona
- National Heart InstituteBeverly Hills, California
- Ark Clinical ResearchLong Beach, California
- Catalina Research Institute, LLCMontclair, California
- Valley Clinical Trials, Inc.Northridge, California