Randomized, Placebo-Controlled Pilot Study of Propranolol for Treating Misophonia
Bloom Mental Health, LLC
Summary
The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia. The secondary goals of this study are: 1. Determine potential predictors of response to propranolol treatment, including demographic factors, baseline symptom severity, psychometric instrument item responses, and physiological characteristics. 2. Evaluate the safety and tolerability of propranolol in individuals with misophonia.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18-65. * Able to complete study visit(s) in Littleton, CO. * Able to give informed consent. * Participant reports clinically significant misophonia symptoms, as determined by answers on the standardized "Misophonia Trigger Screening Questions for Participants" form (described separately in the protocol). Specifically, participants must demonstrate relevant misophonia trigger responses that meet pre-specified minimum severity criteria detailed on this form. * A-MISO-S rating scale severity criterion: Participants must score at least a moderate ("2") or higher on quest…
Interventions
- Drugpropranolol
A one-time dose of 20 mg propranolol
- DrugPlacebo
A dose of placebo taken orally
Location
- Bloom Mental HealthLittleton, Colorado