A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
Oregon Health and Science University
Summary
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception postpartum will be randomized to norethindrone or drospirenone for 6 weeks following hospital discharge.
Description
In this open-label, randomized, feasibility trial, we will recruit participants admitted to OHSU after a pregnancy complicated preeclampsia (diagnosed antepartum or postpartum). All patients admitted after a birth are offered contraception as a routine part of clinical care; only prospective participants who are undecided in their birth control method or who are considering a progestin-only pill contraception will be approached for inclusion. Participants who consent for enrollment will be randomized to norethindrone or drospirenone. Prescriptions will be filled by the OHSU research pharmacy…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Admission to Oregon Health \& Science University following a birth (during the same admission) * A diagnosis of preeclampsia or chronic hypertension with superimposed preeclampsia (with or without severe features) * Considering use of a progestin-only pill for postpartum contraception Exclusion Criteria: * Planned use of a contraceptive method other than a progestin-only pill * Contraindications to drospirenone or norethindrone * Inability to monitor blood pressure at home after discharge * Inability to complete follow-up surveys by email in English
Interventions
- DrugNorethindrone 0.35 MG
1 tablet (0.35 mg) once daily, taken at the same time each day between hospital discharge following delivery until 6 weeks postpartum.
- DrugDrospirenone
1 tablet (4 mg) once daily for 24 days, followed by 4 inactive tablets. Repeated from hospital discharge following delivery until 6 weeks postpartum.
Location
- Oregon Health & Science UniversityPortland, Oregon