Case Western Reserve University
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.
Inclusion Criteria: 1. Adults (≥18 years) with type 2 diabetes mellitus (HbA1c ≥ 7.0% and ≤9.5%) 2. Diagnosed with moderate to severe periodontitis (≥5 mm probing pocket depth in at least 6 distinct interproximal sites, on different teeth) 3. At least 16 teeth present 4. No periodontal treatment in the last 6 months Exclusion Criteria: 1. Allergy to minocycline or tetracycline 2. Unable to receive or to tolerate local anesthesia 3. Unable to tolerate tooth instrumentation with ultrasonic instruments. 4. Require IV sedation to receive scaling and root planing 5. Use of antibiotics within the…
Scaling and Root planing + local application of Arestin ( Minocycline microsphere)
Only scaling and root planing
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