The University of Texas at Arlington
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes. Specific aims include: Aim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction. Aim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.
Subjects that do not have peripheral artery disease will complete the study procedures up to two times (baseline and follow-up at 1-2 months). Subjects diagnosed with peripheral artery disease may be asked to complete the study procedures up to 4 separate times (baseline, follow-up at 1-2 weeks, 1-2 months, and 4-6 months). The investigators will work with them to schedule each visit. All participants will provide informed consent prior to participating in the study. The screening procedures will include collecting information about health history, age, sex, race/ethnicity, height, weight, a…
Inclusion Criteria: * Cases, Aim 1 1. 18 or older 2. willing to participate under the conditions described in the informed consent form (ICF) 3. eligible to sign the ICF 4. established diagnosis of PAD confirmed by a physician 5. able to comply with the study requirements * Cases, Aim 2 1\) completed Aim 1 * Controls 1) asymptomatic, with no history or diagnosis of peripheral artery disease Exclusion Criteria: * Cases, Aim 1 1. Ankle-Brachial Index \>0.9 or \<0.4 2. isolated disease in aorta/iliac vessels 3. unstable angina or myocardial infarction in past 12 months 4…
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