M.D. Anderson Cancer Center
This trial aims to implement and compare an evidence- and theory-based intervention strategy (IGNITE-TX Intervention) to support probands and their ARRs in family communication, informed decision-making, and navigation to CGT with standard of care, free genetic testing/counseling, and intervention with free genetic testing/counseling.
Primary Objectives: 1. Determine the impact of IGNITE-TX on the uptake of cascade genetic testing (CGT) in at-risk relatives (ARRs) at 6 months. 2. Use a mixed methods approach, guided by the NIMHD framework, to evaluate the impact of IGNITE-TX on informational, social, and emotional support outcomes within families at 6 months. 3. Employ formative and process evaluations and stakeholder engagement to guide IGNITE-TX implementation and dissemination through the RE-AIM QuEST framework. Secondary Objective: Analyze the correlation of CGT completion rates within families to understand the infl…
Inclusion Criteria: Probands: 1. 18 years of age or older 2. Speaks and reads English or Spanish 3. Resides in the United States 4. Has a pathogenic or suspected pathogenic variant in BRCA1, BRCA2, MLH1, MSH2/EPCAM, MSH6, or PMS2\* 5. Has access to the internet or phone and can send and receive email and/or text messages at a US telephone number. 6. Attests to have at least one at-risk relative who meets inclusion criteria for first-degree relative * For cancer patients who are unaware of their mutation status, we will share existing local and national genetics resources, like those prov…
Participants will complete a questionnaire
Participants will complete a questionnaire
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