A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-88545223 For the Treatment of Participants With Active Psoriatic Arthritis
Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (b) C-reactive protein (CRP) greater than or equal to (\>=) 0.1 milligrams per deciliter (mg/dL) at screening from the central laboratory * Have \>= 1 of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with abs…
Interventions
- DrugJNJ-88545223
JNJ-88545223 will be administered orally.
- DrugPlacebo
Placebo will be administered orally.
Locations (40)
- Unity Health-White County Medical CenterSearcy, Arkansas
- Newport Huntington Medical GroupHuntington Beach, California
- Rheumatology Center of San DiegoSan Diego, California
- American Research, LLCCutler Bay, Florida
- Innovation Medical Research CenterPalmetto Bay, Florida
- Clinical Research of West FloridaTampa, Florida