Movement and Memory After Breast Cancer: The MAMA Trial

Summary

This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.

Eligibility

Age range

50+ years

Sex

Female

Healthy volunteers

No

Interventions

• Procedure
  Accelerometry

  Ancillary studies

• Other
  Aerobic Exercise

  Participate in walking program

• Other
  Electronic Health Record Review

  Ancillary studies

• Procedure
  Functional Magnetic Resonance Imaging

  Undergo fMRI

• Other
  Gait Assessment Test

  Ancillary studies

• Behavioral
  Health Education

  Receive health education

• Other
  Interview

Location