A Randomized Phase II Trial of Induction Cemiplimab Plus Chemotherapy With or Without Fianlimab in Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck

Inclusion Criteria: * Newly diagnosed, pathologically proven, treatment-naïve unresected LA-HNSCC * Stage T3-T4 \[N0-N3\] or any N2a-3 \[T1-T4\] larynx, hypopharynx, oral cavity, or p16(-) oropharynx (AJCC 8th edition staging) * Stage T4 or N3 p16(+) oropharynx (AJCC 8th edition staging) * Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm with conventional techniques or as ≥10 mm with spiral CT scan, MRI, or calipers b…