Renibus Therapeutics, Inc.
The purpose of this study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD) and metabolic acidosis.
Inclusion Criteria: * Have provided written informed consent prior to participation in the study. * Male or female participants 18 years of age or older. * Diagnosed with CKD (eGFR \< 60 mL/min/1.73m2) and not expected to require renal replacement therapy (dialysis or kidney transplant) throughout the duration of the study. * Within 6 months prior to screening have at least two SBC between 12 and 20 mmol/L, inclusive. If only one historical SBC is available, a second SBC may be drawn on screening visit S1 and analyzed by the local laboratory. * Within screening period have two central laborat…
Group 1: 9 g veverimer BID
Group 2: 9 g PBO BID