Lactiplantibacillus Plantarum 299v Probiotic Probiotic Supplementation in Patients With Diabetic Macular Edema
Massachusetts Eye and Ear Infirmary
Summary
This pilot prospective, interventional, longitudinal study, aims to evaluate the potential benefits of the probiotic supplement Lactobacillus plantarum 299v in patients with diabetic macular edema (DME). The study seeks to address the following questions: 1. Does central macular thickness on optical coherence tomography decrease after 4 months of supplementation? 2. Is visual acuity improved at 1, 2, 3, and 4 months following initiation of supplementation? 3. Is the number of anti-VEGF injections reduced following initiation of supplementation? Outcomes will be compared to a control group, using historic retrospective data. Participants will take Lactobacillus plantarum 299v orally twice daily for four months.
Description
Study Design: Prospective open label longitudinal interventional study with oral probiotic supplement Lactobacillus plantarum. Inclusion criteria: Age of at least 18 years, presence of DME at the current clinical visit Exclusion criteria: Patients with contraindication to probiotic supplement (e.g. prior allergy or GI intolerance and any type of immunocompromised diseases). Eligible individuals (patients at least 18 years old with diabetic macular Participants: Patients with DME that belong in the following two groups: * Group A: 12 Patients with mild DME and good visual acuity (\<= 20/30…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age of at least 18 years, presence of DME at the current clinical visit Exclusion Criteria: * Patients with contraindication to probiotic supplement (e.g. prior allergy or GI intolerance and any type of immunocompromised diseases).
Interventions
- DrugLactobacillus plantarum 299v
Lactiplantibacillus Plantarum 299v Probiotic Supplementation, Twice Daily, for 4 Months
Location
- Mass Eye and EarBoston, Massachusetts