Cook Children's Health Care System
The investigators propose a study that compares breathlessness and airway obstruction during intense exercise in 34 children and adolescents with Exercise-Induced Laryngeal Obstruction after breathing in ipratropium bromide or placebo. It is hypothesized that breathlessness and airway obstruction will be lower following breathing in ipratropium bromide compared with placebo.
Many children and adolescents struggle with breathing problems during exercise. These symptoms can lead them to underperform, quit sports, and in some cases, stop being active altogether. One under-recognized cause is Exercise-Induced Laryngeal Obstruction (EILO), a narrowing of the airway at the level of the voice box. Approximately 5-8% of adolescents and 20-40% of adolescent athletes have EILO, an estimated 4-6 million nationwide. The most common treatment for EILO is Speech Therapy, with or without Physical Therapy. Where available, this requires significant time and financial commitment f…
Inclusion Criteria: * Patients must be diagnosed with EILO confirmed by Continuous Laryngoscopy During Exercise * Patients must be able to complete exercise testing * Patients must report dyspnea * Patients must have given assent with parental consent, understand all study procedures, and comply with them for the entire length of the study. Exclusion Criteria: * Patients that do not have EILO. * Patients who did not undergo diagnostic CPET with CLE. * Patients with hypersensitivity to atropine or its derivatives due to structural similarity with ipratropium bromide. * Patients with a histor…
Nebulized Ipratropium Bromide (500µg/2.5mL); one-time dose approximately 75 minutes before exercise, inhaled for 5-8 minutes
3 mL of nebulized 0.9% normal saline; one-time dose approximately 75 minutes before exercise, inhaled for 5-8 minutes
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