University of Florida
The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).
Inclusion Criteria * Community dwelling men and women 65-89 years old * Ability to walk unassisted for 10 min * English speaking Additional Inclusion Criteria for SCD * No evidence of dementia or MCI based on cognitive screening (i.e., Montreal Cognitive Assessment (MoCA) score within normal limits for age, education, and sex using the NACC Uniform Data Set (UDS) norms * Global Clinic Dementia Rating (CDR) score must be 0 or 0.531 * Subjective report of cognitive complaints with scores \>20 on the Cognitive Change Index (CCI-20), a validated scale of subjective cognitive decline6; this scale…
This group will wear visual occlusion glasses with visible stimulation at 16.67 Hz (corresponding to flicker of 32-36 Hz)
This group will wear visual occlusion glasses with visible stimulation at 1 Hz
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