Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.

Summary

The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp. The main questions it aims to answer are: * Is there a less invasive method to collect useful brain signals? Find out if these brain signals can be related to movement and/or sleep symptoms. * How to use these brain signals to tailor adaptive deep brain stimulation settings for movement and/or sleep symptoms Researchers will compare study derived adaptive DBS settings to subject's clinically programmed continuous DBS settings to see which is better at treating patients PD symptoms.

Description

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Device
  Medtronic Percept Deep Brain Stimulation (cDBS)

  Using the Percept pulse generator, patients receive clinically-optimized open loop stimulation to the subthalmaic nucleus.

• Device
  Medtronic Percept Deep Brain Stimulation (daytime aDBS)

  Using the Percept pulse generator, patients receive daytime adaptive stimulation to the subthalmaic nucleus.

• Device
  Medtronic Percept Deep Brain Stimulation (nighttime aDBS)

  Using the Percept pulse generator, patients receive nighttime adaptive stimulation to the subthalmaic nucleus.

Location