Effects of an Amylopectin Chromium Blend on Whole-Body Protein Kinetics and Glucose Control in Peri/Post-Menopausal Women
Nutrition 21, Inc.
Summary
The goal of this study is to better understand how an amylopectin chromium blend may influence whole body protein balance in women during midlife, when hormonal changes can adversely affect protein metabolism and muscle maintenance. Continuous glucose monitoring will also be used to assess glycemic control over a 24-hour period. The main questions the study aims to answer are: * Does the use of an amylopectin chromium blend in peri- and post-menopausal women help to support positive protein balance * Can the affect be achieved using a concentrated dose Researchers will compare the nutritional supplement to a placebo (amylopectin alone) to see if the amylopectin chromium blend can promote positive protein balance. A concentrated dose of the supplement will also be evaluated for comparative effectiveness. Participants will: * Consume the nutritional supplement (standard or concentrated dose) or placebo acutely after a short resistance exercise bout * Complete four in-person visits, including the single-day intervention Results from this research may help guide future nutritional strategies to support healthy aging, muscle function, and overall metabolic health.
Description
This randomized, double-blind, placebo-controlled clinical trial will evaluate the effects of two dosage forms of an amylopectin-chromium blend on whole-body protein balance in peri- and post-menopausal women. The study will employ a stable isotope tracer methodology to quantify acute changes in protein synthesis and breakdown following a standardized resistance exercise bout and protein ingestion. Continuous glucose monitoring will assess the impact of the supplement on glycemic control over a 24-hour period. Approximately 60 apparently healthy women, aged 40-65 years, will be enrolled at a…
Eligibility
- Age range
- 40–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria:• Women aged 40-65 years who meet either of the following menstrual-history criteria: * ≥ 60 days but \< 12 months of amenorrhea (late perimenopause) * Women with ≥ 12 months of spontaneous amenorrhea (post-menopausal) * No more than 3 days per week of structured physical activity * Provide voluntary signed and dated informed consent. * Be in good health and able to participate in an exercise bout as determined by assessment, medical history, and routine blood chemistries. * Between the of 40 and 65 years of age (inclusive). * Body Mass Index of 18.5-34.9 (inclu…
Interventions
- Dietary SupplementAmylopectin-chromium blend
Amylopectin-chromium blend, 2 g
- Dietary SupplementConcentrated Amylopectin-chromium blend
Amylopectin-chromium blend in a concentrated format (100 mg)
- Dietary SupplementPlacebo
Amylopectin, 2 g
Location
- The Center for Applied Health SciencesCanfield, Ohio